目的:通过研究RhC、c、E、e抗原在宜昌某医院的分布,结合血型不规则抗体的检出情况,浅析Rh抗原C、c、E、e分型检测的临床意义,提高临床用血安全。方法:对我院2022.07~2023.07期间输血患者和献血员进行血清学ABO血型和Rh抗原C、c、E、e分型检测,使用微柱法对用血患者进行血型不规则抗体筛查及鉴定,记录数据后统计并分析。结果:Rh血型表型有8种,出现率最大的为DCCee (46.71%),最小的为DCcEE (0.23%),Rh血型抗原分型检测中CcEe四种抗原的基因频率和抗原依次为e、C、c、E,在输血患者和献血员中分布无统计学意义。随机匹配时,Rh表型相容的比例为65.89%,不相容比例为34.11%。产生的血型不规则抗体占比最高的为Rh系统抗体,占42.9%,其次为MNS系统抗体,占21.43%。结论:Rh表型、CcEe四种抗原的基因频率和抗原分布在输血患者和献血员中均无差异,实行Rh配合性输注有可行性;Rh配合性输注可减少随机输注的风险性。Objective: By studying the distribution of RhC, c, E, and e antigens in a hospital in Yichang, combined with the detection of irregular blood group antibodies, we analyzed the clinical significance of Rh antigen C, c, E, and e typing testing, and improved clinical blood use safety. Methods: Serological ABO blood group and Rh antigen C, c, E, and e typing were performed on blood transfusion patients and blood donors in our hospital during 2022.07~2023.07. The micro-column method was used to screen and identify irregular blood group antibodies on patients who used blood, and the data were recorded and analyzed. Results: There were 8 Rh blood group phenotypes, with the largest occurrence rate being DCCee (46.71%) and the smallest being DCcEE (0.23%). In Rh blood group antigen typing test, the gene frequencies and antigens of the four CcEe antigens weree, C, c, and E in order. There was no statistical significance in the distribution among blood transfusion patients and blood donors. When match
e抗原阴性慢性乙型肝炎病毒(hepatitis B virus,HBV)感染是世界范围内慢性乙型肝炎(chronic hepatitis B,CHB)的主要形式,其管理是世界公共卫生的重大负担。近年,对慢性HBV感染的进一步探索,使得CHB的管理更加精确。欧洲肝病学会提出将CHB自然史分为以下5个阶段:HBeAg阳性HBV感染、HBeAg阳性慢性肝炎、HBeAg阴性HBV感染、HBeAg阴性慢性肝炎、HBeAg阴性HBV感染(隐匿性HBV感染),有相当比例的患者不属于以上任何一个分期,即不确定期。本文总结了关于e抗原阴性HBV感染的文献和指南,旨在帮助临床医师使用无创性工具(如乙肝表面抗原定量和弹性成像)评估HBeAg阴性非活动期与不确定期患者,并及时开始抗病毒治疗。
