目的通过文献计量学分析,全面评估纳米结构脂质载体(NLCs)领域的当前研究状况和趋势。方法使用Web of Science核心合集(WOSCC)收集2003年1-9月间与NLCs研究相关的文章和综述。对收集到的文献数据进行人工筛选。采用VOSviewer、CiteSpace和文献计量学在线分析平台进行计量学分析和可视化处理。结果识别出3312篇NLCs相关文献。国家:印度是其中贡献最多的国家。机构:埃及知识银行(EKB)是最主要机构。作者:Eliana B Souto是发表文章关于NLCs内容最多的作者。热点与前沿:乳腺癌、血脑屏障、局部递送和口服递送是该领域的主要研究方向。结论本研究总结了NLCs领域的出版物特征,明确了最具影响力的国家、机构、作者和期刊,并识别出了研究热点和趋势。这些发现为研究人员提供了对该领域研究现状的深入理解,并为未来研究方向提供了指导。
Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.