糖尿病患者的伤口,尤其是糖尿病足溃疡,比正常伤口更难愈合,容易恶化,导致截肢。普通的治疗方法不能治愈糖尿病伤口或控制其并发症。生长因子在复杂的糖尿病创面愈合过程中起着重要的调节作用。不同的生长因子在糖尿病创面愈合中发挥着不同的作用,这意味着调节不同生长因子以适应伤口愈合的治疗方式可以显著改善糖尿病伤口的治疗。本文就这些生长因子在非糖尿病及糖尿病伤口愈合过程中的具体作用作一综述。Wounds in patients with diabetes mellitus, especially diabetic foot ulcers, are more difficult to heal than normal wounds and can easily deteriorate, leading to amputation. Common treatments cannot heal diabetic wounds or control the complications. Growth factors play an important regulatory role in the complex diabetic wound healing process. Different growth factors play different roles in diabetic wound healing, which means that treatments that modulate different growth factors to adapt to wound healing can significantly improve the treatment of diabetic wounds. This article reviews the specific roles of these growth factors in the healing process of non-diabetic and diabetic wounds.
