帕金森病(Parkinson’s disease, PD)是一种与年龄相关的进行性神经退行性疾病,其发生发展与多巴胺能神经元线粒体功能障碍有关,帕金森病的治疗干预目前仅限于对症治疗,主要是多巴胺能药物和脑深部电刺激术(DBS)。DBS靶点的选择是复杂的,需根据患者的运动性症状、非运动性症状综合考虑,为PD患者在DBS选择合适的目标靶点提供依据。现有DBS靶点的疗效有限,目前所使用的DBS靶点不能解决PD患者的所有症状,临床医生应当根据患者的临床症状来选择合适的DBS靶点。本文论述了PD的发病机制,总结了当前针对PD的脑深部电刺激治疗不同靶点的疗效情况,为PD患者选择合适的目标靶点提供依据,在获得最佳治疗的同时,减少副作用,提高患者的生存质量。Parkinson’s Disease (PD) is an age-related progressive neurodegenerative disease, its occurrence and development are related to mitochondrial dysfunction of dopaminergic neurons. At present, the therapeutic intervention of Parkinson’s disease is limited to symptomatic treatment, mainly dopaminergic drugs and deep brain stimulation (DBS). The selection of the target of DBS is complicated, and it needs to be comprehensively considered according to the motor symptoms and non-motor symptoms of patients, so as to provide a basis for the selection of appropriate targets in DBS for patients with PD. The efficacy of existing DBS targets is limited, and the DBS targets currently used can not solve all the symptoms of patients with PD. Clinicians should choose the appropriate DBS targets according to the clinical symptoms of patients. This paper discusses the pathogenesis of PD, summarizes the current therapeutic effect of different targets of deep brain stimulation therapy for PD, and provides a basis for patients with PD to select suitable targets to reduce side effects while obtaining the best treatment and improve the quality of life of patients.
