目的:探究单髁膝关节置换(UKA)术后发生下肢深静脉血栓(DVT)的危险因素。方法:回顾性分析2023年1月至2024年5月于我院接受UKA治疗的患者围术期临床资料,通过单因素分析筛选潜在危险因素,将有显著差异的指标纳入多因素Logistic回归进行统计分析,确定UKA术后DVT的独立危险因素,所有统计以P Objective: This study aims to explore the risk factors for DVT after UKA. Method: This was a retrospective study that included patients who underwent UKA at our hospital from January 2023 to May 2024. Data collection included patients’ demographic characteristics, perioperative examinations, imaging data, operative time, tourniquet time, blood loss, and vascular ultrasound findings. Univariate analysis was initially conducted to identify potential risk factors based on differences between groups. Significant differences were included in multivariate Logistic regression analysis to determine the independent risk factors for DVT after UKA. A P-value < 0.05 was considered statistically significant. Results: A total of 174 patients were included in this study, with 32 in the DVT group and 142 in the non-DVT group. Univariate analysis showed significant differences between the two groups in eight factors: age, operative time, blood loss, tourniquet time, postoperative day 1 D-dimer levels, hypertension, anesthesia type, and X-ray grading (P < 0.05). Multivariate Logistic regression further identified age (P = 0.011, OR = 1.127), tourniquet time (P = 0.047, OR = 1.060), postoperative day 1 D-dimer levels (P < 0.001, OR = 1.971), and lower limb X-ray grading (Grade 4) (P = 0.018, OR = 4.527) as independent risk factors for DVT after UKA. Conclusion: The results of this study indicated that age, tourniquet time, postoperative day 1 D-dimer levels, and lower limb X-ray grading (Grade 4) are independent risk factors for DVT after UKA. Surgeons should identify these risk factors in advance and take preventive measures early to reduce the incidence of per